What is the FDA limit for titanium dioxide?
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How can I tell if a product has titanium dioxide in it? How can I avoid the ingredient?
It is suitable as an alternative to titanium dioxide when higher acid resistance is required, such as in adhesive joints and sealants.
For a review published in 2023 in the journal Environmental Pollution, researchers examined E171 as a possible factor promoting obesity-related metabolic disorders. Because gut microbiota play an important role in immune function maintenance and development, and because titanium dioxide as a food additive has been shown to alter gut microbiota, researchers wanted to review “the dysregulations along the gut microbiota-immune system axis after oral TiO2 exposure compared to those reported in obese or diabetic patients, and to highlight potential mechanisms by which foodborne TiO2 nanoparticles may increase the susceptibility to develop obesity-related metabolic disorders.” The study authors discovered recurrent changes in the gut microbiota composition when exposed to titanium dioxide nanoparticles, with an imbalance of intestinal symbiotic microbiota. These changes and imbalances were also reported and played a role in the development of obesity, the authors wrote. This highlights “foodborne TiO2 nanoparticles as an endocrine disruptor-like chemical promoting obesity-related disorders,” the authors concluded.
Although most studies to date show no harmful effects of titanium dioxide consumption, few long-term human studies are available. Therefore, more research is needed to better understand its role in human health (16Trusted Source, 18Trusted Source).
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In general, nanoparticles have been shown to accumulate in the body, particularly in organs in the gastrointestinal tract, along with the liver, spleen, and capillaries of the lungs.
There's also evidence that inhaling titanium dioxide particles can be dangerous. That's mainly a concern for industrial workers. In places where it's produced, or where it's used to make other products, workers can breathe it in as a dust. The Occupational Health and Safety Administration has exposure standards manufacturers must meet.
One of the key advantages of using titanium dioxide in rubber is its ability to enhance the whiteness and brightness of rubber products. This is especially important in applications where aesthetic appeal is a priority, such as in the manufacturing of white or light-colored rubber goods. The high opacity of titanium dioxide allows for better hiding power, ensuring a uniform and attractive finish on rubber surfaces.
titanium dioxide used in rubber



Conclusion
R-996:
Lithopone, an alternative to titanium dioxide
The most common foods containing titanium dioxide are chewing gum, candies, pastries, chocolates, coffee creamers, and cake decorations (1Trusted Source, 3Trusted Source).
Lithopone 30% CAS No. 1345-05-7

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The author thanks Marco Leona, Scientist-in-Charge of the Department of Scientific Research at the Metropolitan Museum of Art for conducting fluorescence spectrometry on Wheel of Fortune and a valuable discussion of the research, as well as Silvia Centeno, Research Scientist at the Metropolitan Museum of Art, who performed Raman analysis on the watercolors and also contributed her insight. The phenomenon of the phosphorescing lithopone was originally discovered during the author's fellowship in the Sherman Fairchild Center for the Conservation of Works on Paper, funded by the Andrew W. Mellon Foundation. The author thanks all her colleagues for their ideas and support during the research of this paper, and special thanks to Rachel Mustalish for her assistance in editing this work.