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This article reviews the uses, benefits, and safety of titanium dioxide.

As early as sixty years ago, zinc sulphide was first thought of as a pigment for coloring India rubber and a patent for the process of its manufacture was issued in England. But it was not until twenty years later that zinc sulphide and its manufacture was seriously considered as a pigment for paint, and in 1874 a patent was issued for a process of manufacturing a white pigment, composed of zinc sulphide and barium sulphate, known as Charlton white, also as Orr's white enamel. This was followed in 1876 by a patent issued to a manufacturer named Griffith and the product, which was similar in character to Charlton white, was known as Griffith's patent zinc white. In 1879 another patent for a more novel process was obtained by Griffith & Cawley, the product made under this process proving the best of the series placed upon the market up to that date. After that time many new processes were patented, all, however, tending to the same object, that of producing a white pigment, composed of zinc sulphide and barium carbonate, the results, however, in many cases ending with failure.

While lithopone and anatase titanium white gained traction between the 1920s and 1950s, by the advent of the First World War, rutile titanium white had started to overshadow them. Their significance in the artist’s palette has since dwindled, and their use as an artist’s pigment is currently nearly obsolete.

Titanium dioxide can form several different shapes, which have different properties. Some shapes can be converted to nanomaterials. Micronized TiO2 (also called “nano” or “nanoparticles”) was introduced in the early 1990s.Nanotechnology and micronization both refer to the practice of creating very small particles sizes of a given material. “Nanoparticles” usually refers to particles smaller than 100 nanometers; a nanometer is 1/1 billionth of a meter. At these small sizes, and at low concentrations, titanium dioxide appears transparent, allowing for effective sunscreens that do not appear white.

For the First Quarter of 2022

1345-05-7

Titanium dioxide manufacturer: Lomon 

The production of ROS was studied on white blood cells as a model to screen the effect on eukaryotic cells after being exposed to samples and solar simulated irradiation (according to the level of penetration under the skin). For that purpose, the leukocytes were separated from anticoagulated fresh blood using the Ficoll-Hypaque reactive in a well-known technique [33]. Then, 50 μL of suspensions of P25TiO₂NPs (0.2 mg/mL and 0.02 mg/mL), vitaminB2@P25TiO₂NPs (0.2 mg/mL and 0.02 mg/mL) and vitamin B2 (0.2 mg/mL and 0.02 mg/mL) were prepared and mixed with 50 μL of white blood cells suspension. A solution of 3% H₂O₂ was used as positive control and PBS as negative control. Then, the samples were irradiated using the LED panel for 3 and 6 h to simulate the light penetration into the skin. Also, a set of samples was kept in the dark as control. Finally, the ROS were detected through the colorimetric assay employing the nitroblue tetrazolium salt (NBT salt) and the absorbance at 650 nm was measured. The experiment was reproduced twice; the standard deviation was calculated and p-value < 0.05 were considered significant.

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