- In conclusion, the price of hydroxyethylcellulose is a complex interplay of numerous factors. It's not just a reflection of raw material costs but also a testament to the dynamic nature of global markets, industry trends, and technological advancements. To navigate this volatility, stakeholders must stay informed about these influences and adapt their strategies accordingly to ensure operational efficiency and sustainability.
- 5. Emulsifying Property HPMC has,。
2)Methyl Cellulose is soluble in cold water, while dissolution in hot water can be challenging. Its aqueous solution is highly stable within a pH range of 3 to 12. It has good compatibility with starch, guar gum, and many surfactants. Gelation occurs when the temperature reaches the gelation temperature.
- The construction industry employs HPMC powder as a waterproofing agent and an additive in concrete mixtures
- HPMC, or Hydroxypropyl Methylcellulose, is a widely used pharmaceutical and industrial polymer with unique properties that make it highly versatile in various applications. Its solubility is a critical aspect that significantly influences its functionality and effectiveness.
- Redispersible polymer powder is a critical component in various industries, providing a wide range of benefits and applications. This versatile material is commonly used in the construction industry to improve the performance and durability of building materials.
For hydroxypropyl cellulose (E 463), the identified NOAEL corresponded to the highest dose 6,000 mg hydroxypropyl cellulose/kg bw per day (by gavage). The most relevant feeding studies with HPMC (E 464) were performed in rats which tolerated up to 10%, corresponding to 9,000 mg test item/kg bw per day. Rabbits tolerated up to 7,500 mg HPMC/kg bw per day administered via the diet (30 day exposure) and dogs up to 1,500 mg HPMC/kg bw per day, in either case being the highest tested dosages. More studies were conducted using sodium carboxy methylcellulose (E 466). The most relevant ones were conducted in rats, with NOAEL values ranging from 4,500 to 9,000 mg test item/kg bw per day (in all cases the highest dose tested). In these studies, some effects (caecum and colonic enlargement, urothelial hyperplasia, nephrocalcinosis, diffuse epithelial hyperplasia in the urinary bladder) were observed, however, not considered of toxicological concern: the findings in the gastrointestinal tract were considered to be a consequence of the accumulation of poorly absorbed water-soluble material and the findings in kidneys and urinary bladder were attributed to the up to fourfold higher concentration of sodium in the test diet compared with the basal diet. In one further study, rats were daily exposed (gavage) to doses equivalent to 0, 500, 2,500 or 5,000 mg/kg bw per day. Animals treated with ≥ 2,500 mg/kg bw per day had soft and pale faeces, which was attributed to the presence of test material and not considered of toxicological relevance. In the absence of any other adverse effects, also for this study, the identified NOAEL was the top dose (5,000 mg/kg bw per day).





The FEEDAP Panel agrees with the approach of the ANS Panel that, although the data set available for the different celluloses is not complete and most of the studies were old and do not meet the current requirements of toxicological testing, the physico-chemical, structural, biological and kinetic similarities between the modified celluloses make it possible to apply a read-across approach among the different celluloses. Overall, the available information allows to conclude that the celluloses (as a group) are of low toxicological concern.