JECFA previously assessed titanium dioxide at its 13th meeting, at which time the expert committee assigned a “not specified” ADI for the additive due to an absence of significant absorption and a lack of toxicological effects in the available experimental animal and human studies. Since its original evaluation by JECFA, titanium dioxide has become a public point of contention, with its ban being introduced (and then subsequently withdrawn) in California legislation in 2023, a legal battle playing out in the EU over the additive’s ban and classification as a carcinogen in 2022, and the European Food Safety Authority (EFSA) calling titanium dioxide unsafe. However, supporters of titanium dioxide say that claims about its dangers are founded in unreliable studies, and some recent research has supported its safety as a food additive.
Even though it is one of the most-produced chemicals, the real and potential benefits of titanium dioxide are not without controversies. Dust inhalation may cause breathing problems. Titanium dioxide has been classified by the International Agency for Research on Cancer as an Group 2B carcinogen, a “possible carcinogen to humans,” based on studies of rats that inhaled the substance.
White powder
The gravimetric determination of titanium dioxide is vital for several reasons. First and foremost, it ensures product consistency and quality, allowing manufacturers to produce coatings and plastics that meet industry standards. In industries where color consistency is crucial, such as paint production, maintaining a uniform concentration of TiO2 is essential to achieving the desired opacity and brightness.
Colorectal tumors and preneoplastic lesions
The year 2016 had shown a strong rebound of China’s TiO2 business in general, according to market intelligence firm CCM. The market situation in 2015 was quite depressed, while in 2016 huge price rises have benefited the financial performance of China’s manufacturers.

ROS were detected through the colorimetric assay employing the nitro-blue tetrazolium salt (NBT salt) by reading the absorbance of the reduced blue molecule.


≤0.3


The Lithopone market is segmented into application, and region. The major applications studied in the global Lithopone market report include paints & coatings, plastics, printing inks, paper & pulps, rubber, leather, linoleum, and others. Region-wise, the market is studied across North America, Europe, Asia-Pacific, and LAMEA.

Infrared spectra were performed (from 400 to 4000 cm−1) in vitamins@P25TiO2NPs samples and the vitamins alone as controls, employing a Nicolet AVATAR 360 Fourier transform infrared spectrophotometer.
DUBLIN--(BUSINESS WIRE)--The Lithopone Market by Application: Global Opportunity Analysis and Industry Forecast, 2020-2027 report has been added to ResearchAndMarkets.com's offering.

Other food manufacturers use titanium dioxide to absorb water and keep moisture from clumping or degrading, Paul Westerhoff, PhD, an environmental engineer at Arizona State University who researches the biological and cellular effects of titanium dioxide, told Health.
Gravimetric Determination of Titanium Dioxide in Industrial Applications


The European Commission banned titanium dioxide as a food additive in the EU in 2022 after the European Food Safety Authority (EFSA) conducted an updated safety assessment of E171 and concluded the panel could not eliminate concerns about its genotoxicity.
Historical references
Nanotoxicology

Genotoxicity refers to the ability of a chemical substance to damage DNA , the genetic material of cells. As genotoxicity may lead to carcinogenic effects, it is essential to assess the potential genotoxic effect of a substance to conclude on its safety.
Faber argued there hasn't been enough change in these federal regulations in the decades following the FDA's approval of titanium dioxide – especially as others increasingly point to potential health consequences.