The evidence also suggests that the toxicity of TiO2 particles may be reduced when eaten as part of the diet. This is because proteins and other molecules in a person's diet can bind to the TiO2 particles. This binding alters the physical and chemical properties of the particles, which influences how they interact with cells, tissues and organs.
Alterations in gut microbiota
Overall, the use of TiO2 in factory settings plays a crucial role in enhancing the quality, performance, and appearance of a wide range of products. Its unique properties make it an invaluable ingredient in various industrial processes, allowing manufacturers to create high-quality, durable, and visually appealing finishes. As technology continues to advance, the demand for TiO2 is expected to grow, further solidifying its importance in the manufacturing industry.
Titanium dioxide manufacturer: Lomon
At our manufacturing facility, we are committed to sustainability and environmental responsibility. We take great care to ensure that our production processes are as environmentally friendly as possible, and we are constantly looking for ways to reduce our carbon footprint. By choosing our nano titanium dioxide products, customers can be confident that they are supporting a company that is dedicated to preserving the planet for future generations.
You can find more information about EFSA’s work in the area of food additives on our website
Reasons for listing: Sichuan Lomon Group Co., Ltd., a well-known brand of titanium dioxide, a famous trademark in Sichuan, a famous brand in Sichuan, a state-recognized enterprise technology center, one of the largest titanium dioxide manufacturers in China, phosphorous chemical, titanium chemical, biochemical It is a large-scale private enterprise group integrating the comprehensive development and utilization of vanadium titanomagnetite.
Lithopone
Mexican researchers sought to evaluate the effects of E171 across a span of conditions in mice, including its influence on behavior, along with the effects on the colon and liver. The research, published in 2020 in the journal Food and Chemical Toxicology, showed that E171 promoted anxiety and induced adenomas, or noncancerous tumors, in the colon. They also found that E171 heightened goblet cells hypertrophy and hyperplasia, which is typically seen in asthma patients and triggered by smoking or external pollutants and toxins. They also noted mucins overexpression in the mice, which can be linked to cancer cell formation.
Analyst Insight
Titanium dioxide (E 171) is authorised as a food additive in the EU according to Annex II of Regulation (EC) No 1333/2008.

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Fig. 8. Selected images of skin stratus treated with P25TiO2NPs 10% (left) and VitaminB2@P25TiO2NPs 10% (right) under light, showing no penetration of the nanoparticles (white arrows) beyond the outer stratum corneum.
For research published in Archives of Toxicology in 2020, scientists fed one group of mice a solution containing titanium dioxide for one month, and compared it to those that did not receive the additive. They found “the richness and evenness of gut microbiota were remarkably decreased and the gut microbial community compositions were significantly changed” in the titanium dioxide group when compared with the control group. The tests also revealed that the titanium dioxide exposure could cause locomotor dysfunction, or mobility issues “by elevating the excitement of enteric neurons, which might spread to the brain via gut-brain communication by vagal pathway.” The researchers concluded: “These findings provide valuable insights into the novel mechanism of TiO2NP-induced neurotoxicity. Understanding the microbiota-gut-brain axis will provide the foundation for potential therapeutic or prevention approaches against TiO2NP-induced gut and brain-related disorders.”