- Understanding the Significance of HPMC (Hydroxypropyl Methylcellulose) Addresses in the Pharmaceutical Industry
- In conclusion, while HPMC is generally considered safe for use in pharmaceuticals, cosmetics, and food products, there can be potential side effects associated with its use. These side effects can range from mild gastrointestinal discomfort to more serious allergic reactions. If you experience any side effects while using products containing HPMC, it is important to seek medical attention. As always, it is best to speak with your healthcare provider before starting any new products to ensure they are safe for you to use.
- Hydroxypropyl methylcellulose (HPMC) is a widely used polymer in various industries due to its unique properties such as viscosity, film-forming ability, and gelation temperature control. In this article, we will discuss the role of HPMC in gelation temperature control and its applications in different fields.
HPMC
The majority of the available studies have been performed in rats, just few of them in rabbits and dogs. Among those meeting the current criteria for toxicological testing, the no observed adverse effect level (NOAEL) values for the different modified celluloses were identified most often corresponding to the highest tested level or changes in body or organ weights. For microcrystalline cellulose (E 460) the identified NOAELs in rats ranged from 3,769 mg/kg body weight (bw) per day to 9,000 mg/kg bw per day and in all cases corresponded to the highest levels of the test substance. For methyl cellulose (E 461), the dose level of 3% in rats (equivalent to 2,700 mg/kw bw per day) was selected as the NOAEL based on a decrease in body and organ weight displayed in male rats administered with the top additive level (10%, equivalent to 9,000 mg/kg bw per day and day).


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