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Overwhelmingly, research that’s relevant to human eating patterns shows us that E171 is safe when ingested normally through foods and drugs (1,2).
States looking to ban titanium dioxide as a food additive
In its statement to USA TODAY, the FDA maintained that, in all post-approvals for food additives, our scientists continue to review relevant new information to determine whether there are safety questions and whether the use of such substance is no longer safe under the Federal Food, Drug, and Cosmetic Act.

excellent white tio2 supplier. The production of TiO2 can have significant environmental impacts, so it is crucial to work with a supplier that prioritizes sustainable practices and minimizes their environmental footprint. An excellent white TiO2 supplier will have certifications and initiatives in place to demonstrate their commitment to sustainability and responsible sourcing.
In addition to controlling the reaction conditions, it is also important to carefully monitor the precipitation process to ensure that the desired precipitation percentage is achieved. This can be done through various analytical techniques, such as X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy, which can provide valuable insights into the particle size distribution, crystallinity, and purity of the titanium dioxide product.
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In some studies, E171 was given to animals in drinking water without the stabilizers that keep E171 suspended in the liquid. Without stabilizers, E171 can settle and prevent the ingredient from combining with surrounding ingredients.
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Fig. 5. ROS values (Abs of NBT) in samples of MSSA treated with A: 0.2 mg/mL P25TiO2NPs; B: 0.02 mg/mL P25TiO2NPs; C: 0.2 mg/mL VitaminB2@P25TiO2NPs; D: 0.02 mg/mL VitaminB2@P25TiO2NPs after 3 h of irradiation (red) and 6 h (blue). SD < 0.20 and p < 0.05 between C-D and A-B.
Conclusion
The precipitation of titanium dioxide involves the reaction of titanium sulfate with an alkaline solution to form titanium hydroxide, which is then calcined to produce titanium dioxide. The precipitation process is crucial for achieving the desired particle size distribution, crystallinity, and purity of the final product.