Other research suggests that E171 could cause harm; however, those research processes did not consider how people are typically exposed to E171. Research that adds E171 to drinking water, utilizes direct injections, or gives research animals E171 through a feeding apparatus is not replicating typical human exposure. 

Overall, CAS 13463-67-7 stands out as a reliable and trustworthy titanium dioxide factory that is committed to delivering top-quality products and services. With its focus on quality, sustainability, and innovation, the factory has established itself as a leader in the industry and a preferred partner for companies looking to source titanium dioxide for their dyes and pigments.

Titanium dioxide prices climbed significantly in the European region during Q2 2021, owing to strong demand from the downstream sector. Major global suppliers indicated that they have seen a surge in its demand for primarily from Europe and Asia, despite a global supply constraint. Furthermore, a global player raised titanium dioxide costs in Europe by 200 USD /MT this quarter, effective Q3 2021.

Recent analyses of food-grade TiO₂ samples have found that a significant portion of particles may be within the nanoscale. These particles (also known as nanoparticles) range in size from 1 to 100 nm, where 1 nm equals 1 billionth of a metre (the width of a typical human hair is 80,000 to 100,000 nm).

Although barium sulfate is almost completely inert, zinc sulfide degrades upon exposure to UV light, leading to darkening of the pigment. The severity of this UV reaction is dependent on a combination of two factors; how much zinc sulfide makes up the pigments formulation, and its total accumulated UV exposure. Depending on these factors the pigment itself can vary in shade over time, ranging from pure white all the way to grey or even black. To suppress this effect, a dopant may be used, such as a small amount of cobalt salts, which would be added to the formulation. This process creates cobalt-doped zinc sulfide. The cobalt salts help to stabilize zinc sulfide so it will not have as severe a reaction to UV exposure.

Fig. 3. Cell survival measured on samples of MSSA with bare and functionalized P25TiO₂NPs after 6 h of irradiation. A: P25TiO₂NPs, B:vitaminB2@P25TiO₂NPs, C: vitaminC@P25TiO₂NPs in concentrations of 0.2 μg/mL (red) and 0.2 mg/mL (blue). p <0.05.

For a mini-review published in the journal Particle and Fibre Technology in 2021, scientists wanted to evaluate whether Ti02 particles contributed to the development and/or exacerbation of irritable bowel disease, and whether they altered the four elements of intestinal barrier function: the intestinal microbiota, the immune system, the mucus layer, and the epithelium. The breakdown of these four elements can contribute to autoimmune, neurological, inflammatory, infectious, and metabolic diseases. Following their review, the researchers concluded: “Data indicate that TiO2 is able to alter the four compartments of IBF and to induce a low-grade intestinal inflammation associated or not with pre-neoplastic lesions.”