Hydroxypropyl methyl cellulose (HPMC) is a cellulose derivative that was first developed and used in industrial and food applications starting in the 20th century. Its exact origin in terms of discovery and initial development is difficult to attribute to a single individual or organization, as research and development of cellulose derivatives has involved many scientists and companies at different times.
HPMC is produced through a chemical process known as etherification, in which natural cellulose is treated with hydroxypropyl chloride and sodium methoxide. This process alters the chemical structure of cellulose, making it water-soluble and giving it desired properties as a thickener, stabilizer and film-forming agent.
Production and Use over Time:
The use of HPMC in industrial and food applications has grown significantly since the mid-20th century, when researchers began to more fully explore the potential uses of cellulose derivatives. Its ability to act as a thickener, emulsifier and stabilizer has increased its adoption in a variety of industries, including pharmaceuticals, cosmetics and food.- In the pharmaceutical industry, HPMC is commonly used as a suspending agent in suspensions, where it helps to keep the suspended particles evenly distributed throughout the liquid. The viscosity grade of HPMC can affect the suspension's stability, with higher viscosity grades providing better stability against sedimentation.
- The viscosity grades of HPMC play a significant role in determining its functionality and end-use application. Viscosity is a measure of a fluid's resistance to flow, and in the case of HPMC, it refers to the thickness or thinness of the solution it forms when mixed with water. The percentage of HPMC, often referred to as HPMC %, directly impacts this property.
- Environmental Sustainability
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Dispersive ophthalmic viscosurgical device (OVD) used to create and maintain anterior chamber depth and visibility, as well as to protect intraocular tissues during surgery.
Why do we use HPMC capsules?
Why is Hydroxypropyl Methylcellulose in Construction?
5. Hydroxypropyl Methylcellulose can mix with water-soluble polymers and then form a uniform solution of higher viscosity, such as polyvinyl alcohol, starch ethers, and vegetable gums.
Answer: HPMC viscosity is inversely proportional to temperature, meaning that viscosity increases as temperature decreases. When we refer to the viscosity of a product, it typically indicates the measurement of its 2% aqueous solution at a temperature of 20 degrees Celsius.
