Historical references

In some studies, E171 was given to animals in drinking water without the stabilizers that keep E171 suspended in the liquid. Without stabilizers, E171 can settle and prevent the ingredient from combining with surrounding ingredients.

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Appearance:

So if you’re worried about titanium dioxide, don’t be! With current research and industry recommendations, titanium dioxide is a safe food additive. And if you want to avoid it, that’s ok too! Just don’t expect certain foods to be so white, smooth, and bright.

In a small study published in the European Journal of Nutrition in 2020, researchers examined the effects of several food additives, including titanium dioxide, along with artificial sweeteners and cleaning products by testing the fecal samples of 13 people. Titanium dioxide was among the samples that “induced significant shifts in microbiome community structure.”  The growth of the bacterium species belonging to C. leptum, which has been shown to decrease in patients with inflammatory bowel disease, “significantly decreased in the presence of … titanium dioxide” among other additives and sweeteners tested.

BaS+ZnSO4→ZnS·BaSO4

If you want to avoid titanium dioxide, Stoiber and Faber urge consumers to try and avoid processed foods as best as you can.

Titanium dioxide is considered safe for use in cosmetics products by expert bodies around the world, including Europe's Scientific Committee on Consumer Safety (SCCS) and the U.S. Food and Drug Administration (FDA). Nano grade titanium dioxide has been assessed by the SCCS and is approved by the European Commission for use as a UV filter.

Importantly, TiO2 also has a very high refractive index (its ability to scatter light), even higher than diamond. This makes it an incredibly bright substance and an ideal material for aesthetic design use.

The surge in demand for interior and exterior paints and use of plastic across various end-use industries drive the global Lithopone market. Lithopone white pigment is used in paints and coating systems that find applications in residential and industrial landscapes. Hence, as the construction & building sector flourishes, the demand for building and architectural materials such as paints and coatings will increase. This trend is conducive for the Lithopone market growth. In addition, white plastic materials are increasingly being used in consumer products. Developments in plastic forming technology is anticipated to indirectly boost plastic production, thus, increasing the demand for white pigments during the forecast period.

For a mini-review published in the journal Particle and Fibre Technology in 2021, scientists wanted to evaluate whether Ti02 particles contributed to the development and/or exacerbation of irritable bowel disease, and whether they altered the four elements of intestinal barrier function: the intestinal microbiota, the immune system, the mucus layer, and the epithelium. The breakdown of these four elements can contribute to autoimmune, neurological, inflammatory, infectious, and metabolic diseases. Following their review, the researchers concluded: “Data indicate that TiO2 is able to alter the four compartments of IBF and to induce a low-grade intestinal inflammation associated or not with pre-neoplastic lesions.”