In a study published in the journal Environmental Toxicology and Pharmacology in 2020, researchers examined the effects of food additives titanium dioxide and silica on the intestinal tract by grouping and feeding mice three different food-grade particles — micro-TiO2, nano-TiO2, and nano-SiO2.  With all three groups, researchers observed changes in the gut microbiota, particularly mucus-associated bacteria. Furthermore, all three groups experienced inflammatory damage to the intestine, but the nano-TiO2 displayed the most pronounced changes. The researchers wrote: “Our results suggest that the toxic effects on the intestine were due to reduced intestinal mucus barrier function and an increase in metabolite lipopolysaccharides which activated the expression of inflammatory factors downstream. In mice exposed to nano-TiO2, the intestinal PKC/TLR4/NF-κB signaling pathway was activated. These findings will raise awareness of toxicities associated with the use of food-grade TiO2 and SiO2.”

A significant body of research, mostly from rodent models and in vitro studies, has linked titanium dioxide with health risks related to the gut, including intestinal inflammation, alterations to the gut microbiota, and more. It is classified by the International Agency for Research on Cancer (IARC) in Group 2B, as possibly carcinogenic to humans.

Titanium dioxide comes in the form of a white powder and is sometimes used in cosmetics to adjust a color to a lighter shade. This is also why it can produce a white cast.

When E171 isn’t combined with other ingredients and administered in water, some studies suggest that under these artificial conditions, E171 may be processed differently in the body resulting in some biological changes in experimental animals that are poorly understood.

It is naturally opaque and bright, which makes it useful for use in paper, ceramics, rubber, textiles, paints, inks and cosmetics.It is also resistant to ultraviolet (UV) light, and is used widely in sunscreens and pigments that are likely to be exposed to UV light. It is used in a wide variety of personal care products, including color cosmetics such as eye shadow and blush, loose and pressed powders and in sunscreens.

Furthermore, lithopone is a versatile pigment that can be easily mixed with other coloring agents to create custom shades and finishes. This flexibility allows leather suppliers to meet the diverse needs of their customers and produce a wide range of leather products in different colors and styles. Whether it's a classic black leather jacket or a trendy pastel-colored purse, lithopone can be tailored to suit any design requirements.

Titanium dioxide comes in the form of a white powder and is sometimes used in cosmetics to adjust a color to a lighter shade. This is also why it can produce a white cast.

The toxicity of P25TiO₂NPs under UV radiation could be even higher when combined with other usual components of sunscreens Indeed, Soler de la Vega et al. advise that combination with parabens increases the toxicity of the final cosmetic mixture [53].

Despite a bullish trends ruling the market for the bulk of the period, the North American market had mixed sentiments in the fourth quarter of 2021. This was mostly due to the adequate pushback from the supply-demand imbalance, which was further compounded by rising natural gas prices, which had taken a proper toll on the future production of numerous minerals, including titanium dioxide. An increase in COVID instances had prompted concerns in ore feedstock. As a result, during the fourth quarter of 2021, the FD UGSC (USA) quarterly average negotiations for the chemical CP Rutile Grade were finalised at USD 4434 per tonne.

Characteristics of Common White Pigments

The ROS seemed to be endlessly produced by P25TiO₂NPs upon irradiation, since the values detected after 6 h are similar to the ones after 3 h. However, the amount of vitamin B2 in the surface of the NPs proved to be enough to decrease the ROS detected even after 6 h. Statistical analysis showed a significant difference between C and A. p < 0.05

Fig. 8. Selected images of skin stratus treated with P25TiO₂NPs 10% (left) and VitaminB2@P25TiO₂NPs 10% (right) under light, showing no penetration of the nanoparticles (white arrows) beyond the outer stratum corneum.

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